I've just bought Mass Effect on Steam and installed it in PortingKit and the game seems to generally work well.
However at a point about 15-20 minutes into the game where I opened a door and spoke to some scientists the voice dialogue - which had been working fine to that point - started to cut out.
A character would say the first couple of words and then their audio would drop out while the scene continued to play. Then another would speak and again you maybe get a word or two before their audio cut out. Music and sound effects continue without any problem.
Unfortunately in a story-driven game being unable to hear what people are telling you is a bit of a disaster so I am hoping there is an easy fix for this?
MacBookPro 13,1 (2.4GHz i7, 16GB RAM, Iris Graphics 540)